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thundara  ·  4057 days ago  ·  link  ·    ·  parent  ·  post: Fyodor Urnov on Genome Editing

In the case of the latter, I talked to one of the researchers who worked on this project. A thing they mentioned was that, after breaking and rejoining the DNA, you don't necessarily need to screen the stem cells for those that integrated the corrected fragment. Once in a human body, at least in the cases of β-thalassemia and sickle cell anemia, there is a selective advantage for the modified stem cells.