Given the limitations of our senses, I imagine that there is something yet to be discovered that will contradict everything we think we know.

I tend to agree. I find the attitude of most scientists and religious fundamentalists to be hubristic. Religious fundamentalists for obvious reasons, and scientists for more subtle ones.

Many scientists attempt to be humble in their language, but fail to be in their actions, as materialism generally presupposes that we know all the big important stuff and we just have details to fill in.

There is more that we don't know than we do know about many areas. That animal experience is a product of cell function alone is one of the more banal of the hubristic attitudes kept by many scientists (neuroscientists being some of the worst offenders), but it's illustrative of the popular reductionist trap that we all fall into at times. Suggesting the universe is an integrated whole is a surefire way to get most of your colleagues to dismiss your opinion out of hand, but I think the evidence suggests it is so when viewed from the top down.

Personally, I'd like to say that I'm an open minded kind of fella, but is anyone, really? I think our biases control our interactions with each other and with the world to a larger extent than most of us are aware.