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Both big problems. Doing crazy shit to cows would create a super plague that might kill people, but will certainly kill buttloads of cows. If it gets bad enough it could kill most or all cows. Doing crazy shit to people will create a super plague that will kill a lot of people, might kill other species. Different probabilities, but lots of badness to be averted by more intelligent agriculture and longitudinal family practice and preventative care.the biggest concern with antibiotic-resistance is in farm animals that are getting pumped full of them as preventative measures.