I think, though, a bigger question might be this: How long should I give a location/job/relationship a chance before bailing out? Location especially, because bailing out of a location will also involve bailing out of the job and often the relationship in that place. I once left a location I loved in order to bail out of a relationship. I didn't feel capable of just moving down the street - had to leave the city, province, territory. Anyway, there are no universal answers to the questions you pose, but thinking and talking about it is probably useful.What, to you, would be skills and issues that would fall into this?
For example, I'm committed to being, say, a teacher and a writer. I would want to find myself a location where I could be those things. I'm also committed to being a mother and a daughter, so I shouldn't go too far from the location where those roles play out.