No, it literally just stopped having any effect on me. It's not like I ever took much - once every 6-9 months or so, for about 2 years - but at some point it just didn't do anything for me. I tend to have an extremely high resistance to pretty much anything. Caffeine. Pain killers. Recreational drugs. And I don't take anything on a regular basis. I even have a fantastic collection of single malt scotch whiskys, and I will have maybe one or two drinks a week. In fact, I wanted to get high the other day on cannabis. But it doesn't have much effect on me, usually. So we went to the cannabis store, talked to the pros there, and the woman gave me two different tinctures to try out. (I had previously tried the Legal Weed coffee drink, which has 40mg of CBD in it, and it had almost no effect on me.) I finally found my sweet spot! 50mg of CBD. FIFTY milligrams!! And it takes about 2 hours to take effect. So yeah... I don't do any sort of drugs often because it simply isn't very predictable.