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I will give a try to uBlock Origin soon, thanks for the tip. Do you use other extensions that you find great ?
In my opinion, the trick to Chrome is to run as few plugins as you can get away with, as every plugin and every tab is a process and the more processes, the slower things run. I run 1password, Ghostery, uBlock Origin and Google Hangouts, and I occasionally disable Google Hangouts because it seems to be a primary cause of Chrome misbehavior.