Oh I didn't mean for that to sound like I PLAY left-handed; on the contrary, I play like any right-handed player would. My reasoning for learning this way was because of the selection I had with "standard" guitars as opposed to their "lefty" counterparts, and being left-hand dominant gives me a little more freedom across the fretboard (although I still have problems doing intricate six string chord patterns on the fly...and sweeps x.x) I used to be in a band with a guy that played lefty though, and picking it up felt like learning guitar all over again. Learning lefty after spending a majority of your time playing regularly is INCREDIBLY difficult, unless you're ambidextrous or naturally talented (in my opinion, YMMV.) To answer the question directly, though: playing left-handed means picking with the left hand, and my right hand does NOT have dexterity to play the genre I enjoy after all these years (metal), so picking up a lefty guitar is a definite drawback.